By jove, perhaps they've got it! Could this be what causes - what explains - anorexia nervosa? This is really big stuff - not only an interesting and elegant model, but immediately useful information. How often does that happen?
The entire paper is available online at the link above, so go get it from the source, or read the excellent overview at the AADT blog above.
Among the highlights:
- "It is likely that the discovery of leptin and its functions will turn out to be the major endocrinological finding in AN to explain symptoms related to semi-starvation."
- "determination of leptin levels in patients with acute AN should thus become part of the routine clinical evaluation at referral"
- Why refeeding seems to make things worse for a while, derailing recovery.
- Why it takes up to a year for the system to recover, inviting relapse.
I look forward to reader feedback on this one - read, discuss!